Also known as the James Valentine Campbell Residence, this house was built in 1877. James Valentine Campbell was born in Buffalo, New York, on February 25, 1823, and moved to Detroit with his parents at the age of three. He spent his entire professional life in the city, serving as both a lawyer and later a justice on the Michigan Supreme Court, a position he held until his death on March 26, 1890, at the age of 76. Campbell lived in this house with his family until his death.

The house stood alongside the George Jerome House and the Charles H. Dickerson residence, forming part of a distinguished stretch of Alfred Street. After the Campbell family, the house, like many single-family homes in the neighborhood, was converted into a rooming house, a use it retained until the late 1970s. By then, much of Alfred Street had already lost numerous structures to demolition in the 1960s, making the Campbell House a rare survivor.

Vacant from the late 1970s, the building steadily deteriorated. Over the years, its original slate roof was removed, leading to structural decay throughout the house. In 2005, the Campbell House, along with the Ransom Gillis House and the neighboring properties at 287 and 295 Alfred, narrowly escaped demolition and was instead mothballed. The house was renovated by Bedrock, alongside 287 and 295 Alfred and is part of the City Modern development's "historic homes" collection, featuring rehabilitated 19th-century architecture situated among new construction town homes and apartments.

Added to the Brush Park Local Historic District: Jan. 23, 1980