The 10,000-square-foot, 24-room mansion was designed by George D. Mason & Co. for Frederick J. Fisher (1878–1941) and his wife Bertha. Fisher was the oldest of seven brothers who made their fortunes manufacturing automobile bodies.

Throughout its history, this home has been owned by only four individuals. Dr. DeWitt Burton, the founder of Burton-Mercy Hospital, and his wife Alice Burton purchased it from the Fishers and remained its owners for 60 years.

Here's a list of properties which at one point all related to the Fisher Family. They can also be found on Historic Detroit:

Fisher Body 21

Fisher Body 37

Alfred J. Fisher Mansion

Charles T. Fisher Mansion

Edward F. Fisher Mansion

Frederick J. Fisher Mansion

Lawrence P. Fisher Mansion

William A. Fisher Mansion

Howard A. Fisher Home

Margaret T. Fisher Mansion

Margaret T. Fisher Home

William A. Fisher House

Fisher Building

YMCA (Fisher Branch)

Fisher Administration Center)